Hepatic drug metabolism by CYP2D6 in critically ill adults with AKI: effect of phenotype and AKI severity
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چکیده
منابع مشابه
Hepatic drug metabolism by CYP2D6 in critically ill adults with AKI: effect of phenotype and AKI severity
Introduction Hepatic drug metabolism by cytochrome P450 type 3A (CYP3A) is impaired in patients with acute kidney injury (AKI) [1]. The mechanisms underlying this are unclear. CYP2D6 is another clinically important hepatic CYP subtype, responsible for approximately 25% drug metabolism. Common phenotypic variation exists, the clinical relevance of which has not been previously demonstrated in th...
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ژورنال
عنوان ژورنال: Intensive Care Medicine Experimental
سال: 2015
ISSN: 2197-425X
DOI: 10.1186/2197-425x-3-s1-a839